Metoclopramide and Tacrolimus: Drug Interaction Guide

Quick answer: This combination requires caution. Metoclopramide and Tacrolimus can be used together with adjustments and monitoring.

How Metoclopramide interacts with Tacrolimus

Metoclopramide increases gastric emptying and may enhance tacrolimus absorption, raising trough levels and risk of nephrotoxicity.

What you should do

Monitor tacrolimus trough levels within one week of starting or stopping metoclopramide and adjust dose to target range.

Key facts

Severity

Moderate — caution required

Mechanism

Metoclopramide increases gastric emptying and may enhance tacrolimus absorption, raising trough levels and risk of nephr...

Action

Monitor tacrolimus trough levels within one week of starting or stopping metoclopramide and adjust dose to target range.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Metoclopramide and Tacrolimus together?

With caution. Monitor tacrolimus trough levels within one week of starting or stopping metoclopramide and adjust dose to target range.

What is the severity of this interaction?

The interaction between Metoclopramide and Tacrolimus is classified as Moderate — caution required. Metoclopramide increases gastric emptying and may enhance tacrolimus absorption, raising trough levels and risk of nephrotoxicity.

What should I do if I'm prescribed both?

Monitor tacrolimus trough levels within one week of starting or stopping metoclopramide and adjust dose to target range. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 17, 2026 by iMedic Medical Editorial Team. Our editorial process.