Metoclopramide and Tetrabenazine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Metoclopramide and Tetrabenazine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Metoclopramide interacts with Tetrabenazine

Both drugs antagonise central dopamine D2 receptors, additively increasing risk of extrapyramidal symptoms, tardive dyskinesia, and neuroleptic malignant syndrome.

What you should do

Avoid the combination; choose ondansetron or a non-dopaminergic antiemetic in patients receiving tetrabenazine for Huntington's chorea.

Key facts

Severity

Major — avoid combination

Mechanism

Both drugs antagonise central dopamine D2 receptors, additively increasing risk of extrapyramidal symptoms, tardive dysk...

Action

Avoid the combination; choose ondansetron or a non-dopaminergic antiemetic in patients receiving tetrabenazine for Hunti...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Metoclopramide and Tetrabenazine together?

No — this combination should generally be avoided. Avoid the combination; choose ondansetron or a non-dopaminergic antiemetic in patients receiving tetrabenazine for Huntington's chorea.

What is the severity of this interaction?

The interaction between Metoclopramide and Tetrabenazine is classified as Major — avoid combination. Both drugs antagonise central dopamine D2 receptors, additively increasing risk of extrapyramidal symptoms, tardive dyskinesia, and neuroleptic malignant syndrome.

What should I do if I'm prescribed both?

Avoid the combination; choose ondansetron or a non-dopaminergic antiemetic in patients receiving tetrabenazine for Huntington's chorea. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.