Midazolam and Posaconazole: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Midazolam and Posaconazole unless specifically directed by your doctor.

How Midazolam interacts with Posaconazole

Posaconazole strongly inhibits CYP3A4, markedly increasing midazolam exposure and risk of prolonged sedation and respiratory depression.

What you should do

Avoid oral midazolam with posaconazole; use an alternative sedative or monitored parenteral dosing if essential.

Key facts

Severity

Major — avoid combination

Mechanism

Posaconazole strongly inhibits CYP3A4, markedly increasing midazolam exposure and risk of prolonged sedation and respira...

Action

Avoid oral midazolam with posaconazole; use an alternative sedative or monitored parenteral dosing if essential.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Midazolam and Posaconazole together?

No — this combination should generally be avoided. Avoid oral midazolam with posaconazole; use an alternative sedative or monitored parenteral dosing if essential.

What is the severity of this interaction?

The interaction between Midazolam and Posaconazole is classified as Major — avoid combination. Posaconazole strongly inhibits CYP3A4, markedly increasing midazolam exposure and risk of prolonged sedation and respiratory depression.

What should I do if I'm prescribed both?

Avoid oral midazolam with posaconazole; use an alternative sedative or monitored parenteral dosing if essential. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 25, 2026 by iMedic Medical Editorial Team. Our editorial process.