Mycophenolate and Tacrolimus: Drug Interaction Guide
Quick answer: Mycophenolate and Tacrolimus have a minor interaction — typically manageable with awareness.
How Mycophenolate interacts with Tacrolimus
Tacrolimus reduces enterohepatic recycling of mycophenolic acid through inhibition of UGT-mediated glucuronidation in the gut, modestly altering MPA exposure compared with ciclosporin co-therapy.
What you should do
No routine dose adjustment required, but consider therapeutic drug monitoring of mycophenolic acid trough levels when switching between calcineurin inhibitors.
Key facts
Severity
Minor — typically manageable
Mechanism
Tacrolimus reduces enterohepatic recycling of mycophenolic acid through inhibition of UGT-mediated glucuronidation in th...
Action
No routine dose adjustment required, but consider therapeutic drug monitoring of mycophenolic acid trough levels when sw...
Frequently asked questions
Can I take Mycophenolate and Tacrolimus together?
Usually yes, with awareness. No routine dose adjustment required, but consider therapeutic drug monitoring of mycophenolic acid trough levels when switching between calcineurin inhibitors.
What is the severity of this interaction?
The interaction between Mycophenolate and Tacrolimus is classified as Minor — typically manageable. Tacrolimus reduces enterohepatic recycling of mycophenolic acid through inhibition of UGT-mediated glucuronidation in the gut, modestly altering MPA exposure compared with ciclosporin co-therapy.
What should I do if I'm prescribed both?
No routine dose adjustment required, but consider therapeutic drug monitoring of mycophenolic acid trough levels when switching between calcineurin inhibitors. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.