Naproxen and Ramipril: Drug Interaction Guide

Quick answer: This combination requires caution. Naproxen and Ramipril can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Naproxen interacts with Ramipril

NSAIDs inhibit renal prostaglandin synthesis, attenuating ACE inhibitor antihypertensive effect and increasing risk of acute kidney injury and hyperkalaemia.

What you should do

Avoid chronic NSAID use with ACE inhibitors where possible, particularly in elderly or volume-depleted patients; monitor renal function and potassium.

Key facts

Severity

Moderate — caution required

Mechanism

NSAIDs inhibit renal prostaglandin synthesis, attenuating ACE inhibitor antihypertensive effect and increasing risk of a...

Action

Avoid chronic NSAID use with ACE inhibitors where possible, particularly in elderly or volume-depleted patients; monitor...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Naproxen and Ramipril together?

With caution. Avoid chronic NSAID use with ACE inhibitors where possible, particularly in elderly or volume-depleted patients; monitor renal function and potassium.

What is the severity of this interaction?

The interaction between Naproxen and Ramipril is classified as Moderate — caution required. NSAIDs inhibit renal prostaglandin synthesis, attenuating ACE inhibitor antihypertensive effect and increasing risk of acute kidney injury and hyperkalaemia.

What should I do if I'm prescribed both?

Avoid chronic NSAID use with ACE inhibitors where possible, particularly in elderly or volume-depleted patients; monitor renal function and potassium. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.