Naproxen and Warfarin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Naproxen and Warfarin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Naproxen interacts with Warfarin

NSAIDs inhibit platelet aggregation, damage gastric mucosa, and displace warfarin from albumin, multiplying bleeding risk additively.

What you should do

Avoid NSAIDs in patients on warfarin. Use paracetamol (≤2 g/day) for analgesia; if NSAID essential, add PPI and monitor INR closely.

Key facts

Severity

Major — avoid combination

Mechanism

NSAIDs inhibit platelet aggregation, damage gastric mucosa, and displace warfarin from albumin, multiplying bleeding ris...

Action

Avoid NSAIDs in patients on warfarin. Use paracetamol (≤2 g/day) for analgesia; if NSAID essential, add PPI and monitor ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Naproxen and Warfarin together?

No — this combination should generally be avoided. Avoid NSAIDs in patients on warfarin. Use paracetamol (≤2 g/day) for analgesia; if NSAID essential, add PPI and monitor INR closely.

What is the severity of this interaction?

The interaction between Naproxen and Warfarin is classified as Major — avoid combination. NSAIDs inhibit platelet aggregation, damage gastric mucosa, and displace warfarin from albumin, multiplying bleeding risk additively.

What should I do if I'm prescribed both?

Avoid NSAIDs in patients on warfarin. Use paracetamol (≤2 g/day) for analgesia; if NSAID essential, add PPI and monitor INR closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.