Nifedipine and Phenytoin: Drug Interaction Guide

Quick answer: This combination requires caution. Nifedipine and Phenytoin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Nifedipine interacts with Phenytoin

Phenytoin induces CYP3A4, increasing nifedipine metabolism and reducing calcium-channel blocker exposure.

What you should do

Monitor blood pressure and angina control; adjust nifedipine dose or consider an antihypertensive less affected by CYP3A induction.

Key facts

Severity

Moderate — caution required

Mechanism

Phenytoin induces CYP3A4, increasing nifedipine metabolism and reducing calcium-channel blocker exposure.

Action

Monitor blood pressure and angina control; adjust nifedipine dose or consider an antihypertensive less affected by CYP3A...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Nifedipine and Phenytoin together?

With caution. Monitor blood pressure and angina control; adjust nifedipine dose or consider an antihypertensive less affected by CYP3A induction.

What is the severity of this interaction?

The interaction between Nifedipine and Phenytoin is classified as Moderate — caution required. Phenytoin induces CYP3A4, increasing nifedipine metabolism and reducing calcium-channel blocker exposure.

What should I do if I'm prescribed both?

Monitor blood pressure and angina control; adjust nifedipine dose or consider an antihypertensive less affected by CYP3A induction. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.