Nifedipine and Tacrolimus: Drug Interaction Guide

Quick answer: This combination requires caution. Nifedipine and Tacrolimus can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Nifedipine interacts with Tacrolimus

Nifedipine and tacrolimus both undergo CYP3A4 metabolism; nifedipine increases tacrolimus exposure through competitive inhibition, raising nephrotoxicity risk.

What you should do

Monitor tacrolimus trough levels and renal function within 5-7 days of initiating nifedipine; reduce tacrolimus dose if levels rise.

Key facts

Severity

Moderate — caution required

Mechanism

Nifedipine and tacrolimus both undergo CYP3A4 metabolism; nifedipine increases tacrolimus exposure through competitive i...

Action

Monitor tacrolimus trough levels and renal function within 5-7 days of initiating nifedipine; reduce tacrolimus dose if ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Nifedipine and Tacrolimus together?

With caution. Monitor tacrolimus trough levels and renal function within 5-7 days of initiating nifedipine; reduce tacrolimus dose if levels rise.

What is the severity of this interaction?

The interaction between Nifedipine and Tacrolimus is classified as Moderate — caution required. Nifedipine and tacrolimus both undergo CYP3A4 metabolism; nifedipine increases tacrolimus exposure through competitive inhibition, raising nephrotoxicity risk.

What should I do if I'm prescribed both?

Monitor tacrolimus trough levels and renal function within 5-7 days of initiating nifedipine; reduce tacrolimus dose if levels rise. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.