Nitrofurantoin and Norfloxacin: Drug Interaction Guide

Quick answer: This combination requires caution. Nitrofurantoin and Norfloxacin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Nitrofurantoin interacts with Norfloxacin

Quinolones antagonise the bactericidal action of nitrofurantoin in vitro and may reduce urinary tract efficacy when used concurrently.

What you should do

Do not coadminister for the same urinary tract infection; choose one agent based on culture sensitivities and local resistance patterns.

Key facts

Severity

Moderate — caution required

Mechanism

Quinolones antagonise the bactericidal action of nitrofurantoin in vitro and may reduce urinary tract efficacy when used...

Action

Do not coadminister for the same urinary tract infection; choose one agent based on culture sensitivities and local resi...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Nitrofurantoin and Norfloxacin together?

With caution. Do not coadminister for the same urinary tract infection; choose one agent based on culture sensitivities and local resistance patterns.

What is the severity of this interaction?

The interaction between Nitrofurantoin and Norfloxacin is classified as Moderate — caution required. Quinolones antagonise the bactericidal action of nitrofurantoin in vitro and may reduce urinary tract efficacy when used concurrently.

What should I do if I'm prescribed both?

Do not coadminister for the same urinary tract infection; choose one agent based on culture sensitivities and local resistance patterns. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.