Nsaid and Warfarin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Nsaid and Warfarin unless specifically directed by your doctor.
How Nsaid interacts with Warfarin
NSAIDs impair platelet function, damage gastric mucosa and (for some agents) displace warfarin from albumin, additively increasing the risk of gastrointestinal and other bleeding.
What you should do
Avoid systemic NSAIDs; use paracetamol or topical NSAIDs for analgesia and add a PPI if a short NSAID course is unavoidable with close INR monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
NSAIDs impair platelet function, damage gastric mucosa and (for some agents) displace warfarin from albumin, additively ...
Action
Avoid systemic NSAIDs; use paracetamol or topical NSAIDs for analgesia and add a PPI if a short NSAID course is unavoida...
Frequently asked questions
Can I take Nsaid and Warfarin together?
No — this combination should generally be avoided. Avoid systemic NSAIDs; use paracetamol or topical NSAIDs for analgesia and add a PPI if a short NSAID course is unavoidable with close INR monitoring.
What is the severity of this interaction?
The interaction between Nsaid and Warfarin is classified as Major — avoid combination. NSAIDs impair platelet function, damage gastric mucosa and (for some agents) displace warfarin from albumin, additively increasing the risk of gastrointestinal and other bleeding.
What should I do if I'm prescribed both?
Avoid systemic NSAIDs; use paracetamol or topical NSAIDs for analgesia and add a PPI if a short NSAID course is unavoidable with close INR monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.