Nsaids and Warfarin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Nsaids and Warfarin unless specifically directed by your doctor.
How Nsaids interacts with Warfarin
NSAIDs displace warfarin from plasma proteins, inhibit platelet aggregation, and cause gastric mucosal injury, markedly increasing bleeding risk.
What you should do
Avoid systemic NSAIDs in anticoagulated patients; prefer paracetamol or topical NSAIDs and add gastroprotection if combination is unavoidable.
Key facts
Severity
Major — avoid combination
Mechanism
NSAIDs displace warfarin from plasma proteins, inhibit platelet aggregation, and cause gastric mucosal injury, markedly ...
Action
Avoid systemic NSAIDs in anticoagulated patients; prefer paracetamol or topical NSAIDs and add gastroprotection if combi...
Frequently asked questions
Can I take Nsaids and Warfarin together?
No — this combination should generally be avoided. Avoid systemic NSAIDs in anticoagulated patients; prefer paracetamol or topical NSAIDs and add gastroprotection if combination is unavoidable.
What is the severity of this interaction?
The interaction between Nsaids and Warfarin is classified as Major — avoid combination. NSAIDs displace warfarin from plasma proteins, inhibit platelet aggregation, and cause gastric mucosal injury, markedly increasing bleeding risk.
What should I do if I'm prescribed both?
Avoid systemic NSAIDs in anticoagulated patients; prefer paracetamol or topical NSAIDs and add gastroprotection if combination is unavoidable. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.