Omeprazole and Tacrolimus: Drug Interaction Guide

Quick answer: This combination requires caution. Omeprazole and Tacrolimus can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Omeprazole interacts with Tacrolimus

Omeprazole inhibits CYP3A4 and CYP2C19, particularly in CYP2C19 poor metabolizers, increasing tacrolimus levels and risk of nephrotoxicity.

What you should do

Monitor tacrolimus trough levels when starting or stopping omeprazole. Consider pantoprazole as alternative PPI with lower interaction potential.

Key facts

Severity

Moderate — caution required

Mechanism

Omeprazole inhibits CYP3A4 and CYP2C19, particularly in CYP2C19 poor metabolizers, increasing tacrolimus levels and risk...

Action

Monitor tacrolimus trough levels when starting or stopping omeprazole. Consider pantoprazole as alternative PPI with low...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Omeprazole and Tacrolimus together?

With caution. Monitor tacrolimus trough levels when starting or stopping omeprazole. Consider pantoprazole as alternative PPI with lower interaction potential.

What is the severity of this interaction?

The interaction between Omeprazole and Tacrolimus is classified as Moderate — caution required. Omeprazole inhibits CYP3A4 and CYP2C19, particularly in CYP2C19 poor metabolizers, increasing tacrolimus levels and risk of nephrotoxicity.

What should I do if I'm prescribed both?

Monitor tacrolimus trough levels when starting or stopping omeprazole. Consider pantoprazole as alternative PPI with lower interaction potential. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.