Omeprazole and Warfarin: Drug Interaction Guide

Quick answer: Omeprazole and Warfarin have a minor interaction — typically manageable with awareness.

How Omeprazole interacts with Warfarin

Omeprazole can inhibit CYP2C19 and may modestly affect metabolism of some warfarin enantiomers. Clinically important INR changes are uncommon but possible.

What you should do

Continue if clinically indicated. Check INR after initiation or dose changes in patients with unstable anticoagulation.

Key facts

Severity

Minor — typically manageable

Mechanism

Omeprazole can inhibit CYP2C19 and may modestly affect metabolism of some warfarin enantiomers. Clinically important INR...

Action

Continue if clinically indicated. Check INR after initiation or dose changes in patients with unstable anticoagulation.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Omeprazole and Warfarin together?

Usually yes, with awareness. Continue if clinically indicated. Check INR after initiation or dose changes in patients with unstable anticoagulation.

What is the severity of this interaction?

The interaction between Omeprazole and Warfarin is classified as Minor — typically manageable. Omeprazole can inhibit CYP2C19 and may modestly affect metabolism of some warfarin enantiomers. Clinically important INR changes are uncommon but possible.

What should I do if I'm prescribed both?

Continue if clinically indicated. Check INR after initiation or dose changes in patients with unstable anticoagulation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 24, 2026 by iMedic Medical Editorial Team. Our editorial process.