Propafenone and Warfarin: Drug Interaction Guide

Quick answer: This combination requires caution. Propafenone and Warfarin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Propafenone interacts with Warfarin

Propafenone inhibits CYP1A2, CYP2C9, and CYP3A4, reducing warfarin clearance and potentiating its anticoagulant effect with INR elevation.

What you should do

Check INR within 5-7 days of initiating propafenone and adjust warfarin dose; routine monitoring thereafter.

Key facts

Severity

Moderate — caution required

Mechanism

Propafenone inhibits CYP1A2, CYP2C9, and CYP3A4, reducing warfarin clearance and potentiating its anticoagulant effect w...

Action

Check INR within 5-7 days of initiating propafenone and adjust warfarin dose; routine monitoring thereafter.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Propafenone and Warfarin together?

With caution. Check INR within 5-7 days of initiating propafenone and adjust warfarin dose; routine monitoring thereafter.

What is the severity of this interaction?

The interaction between Propafenone and Warfarin is classified as Moderate — caution required. Propafenone inhibits CYP1A2, CYP2C9, and CYP3A4, reducing warfarin clearance and potentiating its anticoagulant effect with INR elevation.

What should I do if I'm prescribed both?

Check INR within 5-7 days of initiating propafenone and adjust warfarin dose; routine monitoring thereafter. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.