Propranolol and Rizatriptan: Drug Interaction Guide

Quick answer: This combination requires caution. Propranolol and Rizatriptan can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Propranolol interacts with Rizatriptan

Propranolol inhibits monoamine oxidase A and sulphotransferase metabolism of rizatriptan, increasing rizatriptan AUC by approximately 70%.

What you should do

Reduce rizatriptan dose to 5 mg (maximum 15 mg in 24 hours) when used with propranolol; alternative triptans (sumatriptan, zolmitriptan) do not require adjustment.

Key facts

Severity

Moderate — caution required

Mechanism

Propranolol inhibits monoamine oxidase A and sulphotransferase metabolism of rizatriptan, increasing rizatriptan AUC by ...

Action

Reduce rizatriptan dose to 5 mg (maximum 15 mg in 24 hours) when used with propranolol; alternative triptans (sumatripta...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Propranolol and Rizatriptan together?

With caution. Reduce rizatriptan dose to 5 mg (maximum 15 mg in 24 hours) when used with propranolol; alternative triptans (sumatriptan, zolmitriptan) do not require adjustment.

What is the severity of this interaction?

The interaction between Propranolol and Rizatriptan is classified as Moderate — caution required. Propranolol inhibits monoamine oxidase A and sulphotransferase metabolism of rizatriptan, increasing rizatriptan AUC by approximately 70%.

What should I do if I'm prescribed both?

Reduce rizatriptan dose to 5 mg (maximum 15 mg in 24 hours) when used with propranolol; alternative triptans (sumatriptan, zolmitriptan) do not require adjustment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.