Quinolones and Sucralfate: Drug Interaction Guide

Quick answer: This combination requires caution. Quinolones and Sucralfate can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Quinolones interacts with Sucralfate

Sucralfate's aluminium content chelates fluoroquinolones in the gut, reducing oral bioavailability by up to 90%.

What you should do

Administer fluoroquinolone at least 2 hours before, or 6 hours after, sucralfate; consider alternative gastroprotection.

Key facts

Severity

Moderate — caution required

Mechanism

Sucralfate's aluminium content chelates fluoroquinolones in the gut, reducing oral bioavailability by up to 90%.

Action

Administer fluoroquinolone at least 2 hours before, or 6 hours after, sucralfate; consider alternative gastroprotection.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Quinolones and Sucralfate together?

With caution. Administer fluoroquinolone at least 2 hours before, or 6 hours after, sucralfate; consider alternative gastroprotection.

What is the severity of this interaction?

The interaction between Quinolones and Sucralfate is classified as Moderate — caution required. Sucralfate's aluminium content chelates fluoroquinolones in the gut, reducing oral bioavailability by up to 90%.

What should I do if I'm prescribed both?

Administer fluoroquinolone at least 2 hours before, or 6 hours after, sucralfate; consider alternative gastroprotection. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.