Raltegravir and Rifampicin: Drug Interaction Guide

Quick answer: This combination requires caution. Raltegravir and Rifampicin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Raltegravir interacts with Rifampicin

Rifampicin induces UGT1A1, the enzyme responsible for raltegravir glucuronidation, reducing raltegravir plasma concentrations and risking virologic failure.

What you should do

Double raltegravir dose to 800 mg twice daily when co-administered with rifampicin, or switch rifampicin to rifabutin.

Key facts

Severity

Moderate — caution required

Mechanism

Rifampicin induces UGT1A1, the enzyme responsible for raltegravir glucuronidation, reducing raltegravir plasma concentra...

Action

Double raltegravir dose to 800 mg twice daily when co-administered with rifampicin, or switch rifampicin to rifabutin.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Raltegravir and Rifampicin together?

With caution. Double raltegravir dose to 800 mg twice daily when co-administered with rifampicin, or switch rifampicin to rifabutin.

What is the severity of this interaction?

The interaction between Raltegravir and Rifampicin is classified as Moderate — caution required. Rifampicin induces UGT1A1, the enzyme responsible for raltegravir glucuronidation, reducing raltegravir plasma concentrations and risking virologic failure.

What should I do if I'm prescribed both?

Double raltegravir dose to 800 mg twice daily when co-administered with rifampicin, or switch rifampicin to rifabutin. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.