Rasagiline and Sertraline: Drug Interaction Guide

Quick answer: This combination requires caution. Rasagiline and Sertraline can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Rasagiline interacts with Sertraline

Rasagiline inhibits monoamine oxidase B and sertraline increases serotonergic neurotransmission by serotonin reuptake inhibition. Combined serotonergic effects may increase the risk of serotonin syndrome.

What you should do

Avoid high-risk dosing and monitor for agitation, tremor, hyperreflexia, fever, and autonomic instability. Use only when benefits justify risk and counsel patients on warning symptoms.

Key facts

Severity

Moderate — caution required

Mechanism

Rasagiline inhibits monoamine oxidase B and sertraline increases serotonergic neurotransmission by serotonin reuptake in...

Action

Avoid high-risk dosing and monitor for agitation, tremor, hyperreflexia, fever, and autonomic instability. Use only when...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Rasagiline and Sertraline together?

With caution. Avoid high-risk dosing and monitor for agitation, tremor, hyperreflexia, fever, and autonomic instability. Use only when benefits justify risk and counsel patients on warning symptoms.

What is the severity of this interaction?

The interaction between Rasagiline and Sertraline is classified as Moderate — caution required. Rasagiline inhibits monoamine oxidase B and sertraline increases serotonergic neurotransmission by serotonin reuptake inhibition. Combined serotonergic effects may increase the risk of serotonin syndrome.

What should I do if I'm prescribed both?

Avoid high-risk dosing and monitor for agitation, tremor, hyperreflexia, fever, and autonomic instability. Use only when benefits justify risk and counsel patients on warning symptoms. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.