Repaglinide and Trimethoprim: Drug Interaction Guide

Quick answer: This combination requires caution. Repaglinide and Trimethoprim can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Repaglinide interacts with Trimethoprim

Trimethoprim can inhibit CYP2C8, which contributes to repaglinide metabolism. Increased repaglinide exposure may increase the risk of hypoglycaemia.

What you should do

Monitor blood glucose closely and consider temporary repaglinide dose reduction. Advise patients to recognize and treat hypoglycaemia.

Key facts

Severity

Moderate — caution required

Mechanism

Trimethoprim can inhibit CYP2C8, which contributes to repaglinide metabolism. Increased repaglinide exposure may increas...

Action

Monitor blood glucose closely and consider temporary repaglinide dose reduction. Advise patients to recognize and treat ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Repaglinide and Trimethoprim together?

With caution. Monitor blood glucose closely and consider temporary repaglinide dose reduction. Advise patients to recognize and treat hypoglycaemia.

What is the severity of this interaction?

The interaction between Repaglinide and Trimethoprim is classified as Moderate — caution required. Trimethoprim can inhibit CYP2C8, which contributes to repaglinide metabolism. Increased repaglinide exposure may increase the risk of hypoglycaemia.

What should I do if I'm prescribed both?

Monitor blood glucose closely and consider temporary repaglinide dose reduction. Advise patients to recognize and treat hypoglycaemia. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.