Ribavirin and Zidovudine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ribavirin and Zidovudine unless specifically directed by your doctor.
How Ribavirin interacts with Zidovudine
Ribavirin inhibits phosphorylation of zidovudine to its active form, reducing antiviral activity, while both drugs cause additive haematological toxicity.
What you should do
Avoid co-administration in HIV/HCV co-infection. Use tenofovir-based antiretroviral regimens during HCV treatment.
Key facts
Severity
Major — avoid combination
Mechanism
Ribavirin inhibits phosphorylation of zidovudine to its active form, reducing antiviral activity, while both drugs cause...
Action
Avoid co-administration in HIV/HCV co-infection. Use tenofovir-based antiretroviral regimens during HCV treatment.
Frequently asked questions
Can I take Ribavirin and Zidovudine together?
No — this combination should generally be avoided. Avoid co-administration in HIV/HCV co-infection. Use tenofovir-based antiretroviral regimens during HCV treatment.
What is the severity of this interaction?
The interaction between Ribavirin and Zidovudine is classified as Major — avoid combination. Ribavirin inhibits phosphorylation of zidovudine to its active form, reducing antiviral activity, while both drugs cause additive haematological toxicity.
What should I do if I'm prescribed both?
Avoid co-administration in HIV/HCV co-infection. Use tenofovir-based antiretroviral regimens during HCV treatment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.