Rosuvastatin and Warfarin: Drug Interaction Guide

Quick answer: This combination requires caution. Rosuvastatin and Warfarin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Rosuvastatin interacts with Warfarin

Rosuvastatin may potentiate warfarin's effect through displacement from plasma proteins and modest CYP2C9 effects, increasing INR unpredictably.

What you should do

Check INR within 5-7 days of starting, stopping or changing rosuvastatin dose and adjust warfarin as needed.

Key facts

Severity

Moderate — caution required

Mechanism

Rosuvastatin may potentiate warfarin's effect through displacement from plasma proteins and modest CYP2C9 effects, incre...

Action

Check INR within 5-7 days of starting, stopping or changing rosuvastatin dose and adjust warfarin as needed.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Rosuvastatin and Warfarin together?

With caution. Check INR within 5-7 days of starting, stopping or changing rosuvastatin dose and adjust warfarin as needed.

What is the severity of this interaction?

The interaction between Rosuvastatin and Warfarin is classified as Moderate — caution required. Rosuvastatin may potentiate warfarin's effect through displacement from plasma proteins and modest CYP2C9 effects, increasing INR unpredictably.

What should I do if I'm prescribed both?

Check INR within 5-7 days of starting, stopping or changing rosuvastatin dose and adjust warfarin as needed. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.