Sacubitril Valsartan and Sildenafil: Drug Interaction Guide

Quick answer: This combination requires caution. Sacubitril Valsartan and Sildenafil can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Sacubitril Valsartan interacts with Sildenafil

Both drugs lower systemic vascular resistance — sacubitril/valsartan via natriuretic peptide potentiation and RAS blockade, sildenafil via PDE5 inhibition — producing additive hypotension.

What you should do

Counsel patients on symptomatic hypotension; separate doses, start sildenafil at lowest dose, and monitor blood pressure on initiation.

Key facts

Severity

Moderate — caution required

Mechanism

Both drugs lower systemic vascular resistance — sacubitril/valsartan via natriuretic peptide potentiation and RAS blocka...

Action

Counsel patients on symptomatic hypotension; separate doses, start sildenafil at lowest dose, and monitor blood pressure...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Sacubitril Valsartan and Sildenafil together?

With caution. Counsel patients on symptomatic hypotension; separate doses, start sildenafil at lowest dose, and monitor blood pressure on initiation.

What is the severity of this interaction?

The interaction between Sacubitril Valsartan and Sildenafil is classified as Moderate — caution required. Both drugs lower systemic vascular resistance — sacubitril/valsartan via natriuretic peptide potentiation and RAS blockade, sildenafil via PDE5 inhibition — producing additive hypotension.

What should I do if I'm prescribed both?

Counsel patients on symptomatic hypotension; separate doses, start sildenafil at lowest dose, and monitor blood pressure on initiation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.