Sotalol and Trimethoprim: Drug Interaction Guide

Quick answer: This combination requires caution. Sotalol and Trimethoprim can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Sotalol interacts with Trimethoprim

Trimethoprim can reduce renal tubular secretion of cationic drugs and may increase sotalol exposure in susceptible patients. Higher sotalol levels increase bradycardia and QT prolongation risk.

What you should do

Use caution in renal impairment and monitor renal function, heart rate, and ECG. Consider an alternative antibiotic for patients at high risk of torsades de pointes.

Key facts

Severity

Moderate — caution required

Mechanism

Trimethoprim can reduce renal tubular secretion of cationic drugs and may increase sotalol exposure in susceptible patie...

Action

Use caution in renal impairment and monitor renal function, heart rate, and ECG. Consider an alternative antibiotic for ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Sotalol and Trimethoprim together?

With caution. Use caution in renal impairment and monitor renal function, heart rate, and ECG. Consider an alternative antibiotic for patients at high risk of torsades de pointes.

What is the severity of this interaction?

The interaction between Sotalol and Trimethoprim is classified as Moderate — caution required. Trimethoprim can reduce renal tubular secretion of cationic drugs and may increase sotalol exposure in susceptible patients. Higher sotalol levels increase bradycardia and QT prolongation risk.

What should I do if I'm prescribed both?

Use caution in renal impairment and monitor renal function, heart rate, and ECG. Consider an alternative antibiotic for patients at high risk of torsades de pointes. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.