Theophylline and Thiabendazole: Drug Interaction Guide

Quick answer: Theophylline and Thiabendazole have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Theophylline interacts with Thiabendazole

Thiabendazole can inhibit hepatic metabolism of theophylline, likely involving CYP1A2-related clearance pathways. This may increase theophylline concentrations and adverse effects.

What you should do

Use caution during short courses and monitor for nausea, tremor, palpitations, or insomnia. Consider checking theophylline concentrations in higher-risk patients.

Key facts

Severity

Minor — typically manageable

Mechanism

Thiabendazole can inhibit hepatic metabolism of theophylline, likely involving CYP1A2-related clearance pathways. This m...

Action

Use caution during short courses and monitor for nausea, tremor, palpitations, or insomnia. Consider checking theophylli...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Theophylline and Thiabendazole together?

Usually yes, with awareness. Use caution during short courses and monitor for nausea, tremor, palpitations, or insomnia. Consider checking theophylline concentrations in higher-risk patients.

What is the severity of this interaction?

The interaction between Theophylline and Thiabendazole is classified as Minor — typically manageable. Thiabendazole can inhibit hepatic metabolism of theophylline, likely involving CYP1A2-related clearance pathways. This may increase theophylline concentrations and adverse effects.

What should I do if I'm prescribed both?

Use caution during short courses and monitor for nausea, tremor, palpitations, or insomnia. Consider checking theophylline concentrations in higher-risk patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.