Theophylline and Ticlopidine: Drug Interaction Guide

Quick answer: This combination requires caution. Theophylline and Ticlopidine can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Theophylline interacts with Ticlopidine

Ticlopidine inhibits CYP1A2, reducing theophylline clearance by approximately 40% and increasing risk of theophylline toxicity (arrhythmias, seizures).

What you should do

Reduce theophylline dose by 30-50% and monitor serum levels within one week of initiation. Watch for nausea, tremor, tachycardia.

Key facts

Severity

Moderate — caution required

Mechanism

Ticlopidine inhibits CYP1A2, reducing theophylline clearance by approximately 40% and increasing risk of theophylline to...

Action

Reduce theophylline dose by 30-50% and monitor serum levels within one week of initiation. Watch for nausea, tremor, tac...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Theophylline and Ticlopidine together?

With caution. Reduce theophylline dose by 30-50% and monitor serum levels within one week of initiation. Watch for nausea, tremor, tachycardia.

What is the severity of this interaction?

The interaction between Theophylline and Ticlopidine is classified as Moderate — caution required. Ticlopidine inhibits CYP1A2, reducing theophylline clearance by approximately 40% and increasing risk of theophylline toxicity (arrhythmias, seizures).

What should I do if I'm prescribed both?

Reduce theophylline dose by 30-50% and monitor serum levels within one week of initiation. Watch for nausea, tremor, tachycardia. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.