Ticagrelor and Verapamil: Drug Interaction Guide

Quick answer: This combination requires caution. Ticagrelor and Verapamil can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ticagrelor interacts with Verapamil

Verapamil inhibits CYP3A4 and P-glycoprotein, increasing ticagrelor exposure and the active metabolite AR-C124910XX, enhancing platelet inhibition and bleeding risk.

What you should do

Use with caution; monitor for bleeding and consider alternative rate-control agents such as bisoprolol when feasible.

Key facts

Severity

Moderate — caution required

Mechanism

Verapamil inhibits CYP3A4 and P-glycoprotein, increasing ticagrelor exposure and the active metabolite AR-C124910XX, enh...

Action

Use with caution; monitor for bleeding and consider alternative rate-control agents such as bisoprolol when feasible.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ticagrelor and Verapamil together?

With caution. Use with caution; monitor for bleeding and consider alternative rate-control agents such as bisoprolol when feasible.

What is the severity of this interaction?

The interaction between Ticagrelor and Verapamil is classified as Moderate — caution required. Verapamil inhibits CYP3A4 and P-glycoprotein, increasing ticagrelor exposure and the active metabolite AR-C124910XX, enhancing platelet inhibition and bleeding risk.

What should I do if I'm prescribed both?

Use with caution; monitor for bleeding and consider alternative rate-control agents such as bisoprolol when feasible. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.