Alcohol and Disulfiram: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Alcohol and Disulfiram unless specifically directed by your doctor.
How Alcohol interacts with Disulfiram
Disulfiram inhibits aldehyde dehydrogenase, causing accumulation of acetaldehyde when ethanol is consumed, producing flushing, tachycardia, nausea, and hypotension.
What you should do
Counsel patient to avoid all alcohol including in medications, mouthwash, and food sources for at least 14 days after stopping disulfiram.
Key facts
Severity
Major — avoid combination
Mechanism
Disulfiram inhibits aldehyde dehydrogenase, causing accumulation of acetaldehyde when ethanol is consumed, producing flu...
Action
Counsel patient to avoid all alcohol including in medications, mouthwash, and food sources for at least 14 days after st...
Frequently asked questions
Can I take Alcohol and Disulfiram together?
No — this combination should generally be avoided. Counsel patient to avoid all alcohol including in medications, mouthwash, and food sources for at least 14 days after stopping disulfiram.
What is the severity of this interaction?
The interaction between Alcohol and Disulfiram is classified as Major — avoid combination. Disulfiram inhibits aldehyde dehydrogenase, causing accumulation of acetaldehyde when ethanol is consumed, producing flushing, tachycardia, nausea, and hypotension.
What should I do if I'm prescribed both?
Counsel patient to avoid all alcohol including in medications, mouthwash, and food sources for at least 14 days after stopping disulfiram. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.