Alcohol and Zopiclone: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Alcohol and Zopiclone unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Alcohol interacts with Zopiclone

Alcohol and zopiclone produce additive central nervous system depression through GABAergic sedative effects. Combined use increases impairment, respiratory depression, falls and complex sleep-related behaviours.

What you should do

Advise patients not to drink alcohol while taking zopiclone. Avoid prescribing zopiclone when ongoing alcohol use is likely or uncontrolled.

Key facts

Severity

Major — avoid combination

Mechanism

Alcohol and zopiclone produce additive central nervous system depression through GABAergic sedative effects. Combined us...

Action

Advise patients not to drink alcohol while taking zopiclone. Avoid prescribing zopiclone when ongoing alcohol use is lik...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Alcohol and Zopiclone together?

No — this combination should generally be avoided. Advise patients not to drink alcohol while taking zopiclone. Avoid prescribing zopiclone when ongoing alcohol use is likely or uncontrolled.

What is the severity of this interaction?

The interaction between Alcohol and Zopiclone is classified as Major — avoid combination. Alcohol and zopiclone produce additive central nervous system depression through GABAergic sedative effects. Combined use increases impairment, respiratory depression, falls and complex sleep-related behaviours.

What should I do if I'm prescribed both?

Advise patients not to drink alcohol while taking zopiclone. Avoid prescribing zopiclone when ongoing alcohol use is likely or uncontrolled. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.