Amiodarone and Dabigatran: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Amiodarone and Dabigatran unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Amiodarone interacts with Dabigatran

Amiodarone inhibits P-glycoprotein (P-gp) efflux transporter in the gut and kidney, increasing dabigatran absorption and reducing its renal clearance, leading to elevated plasma concentrations and bleeding risk.

What you should do

Reduce dabigatran dose to 110 mg twice daily when co-administered, especially in patients with CrCl 30–50 mL/min. Monitor for bleeding signs and consider alternative anticoagulation in elderly patients.

Key facts

Severity

Major — avoid combination

Mechanism

Amiodarone inhibits P-glycoprotein (P-gp) efflux transporter in the gut and kidney, increasing dabigatran absorption and...

Action

Reduce dabigatran dose to 110 mg twice daily when co-administered, especially in patients with CrCl 30–50 mL/min. Monito...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amiodarone and Dabigatran together?

No — this combination should generally be avoided. Reduce dabigatran dose to 110 mg twice daily when co-administered, especially in patients with CrCl 30–50 mL/min. Monitor for bleeding signs and consider alternative anticoagulation in elderly patients.

What is the severity of this interaction?

The interaction between Amiodarone and Dabigatran is classified as Major — avoid combination. Amiodarone inhibits P-glycoprotein (P-gp) efflux transporter in the gut and kidney, increasing dabigatran absorption and reducing its renal clearance, leading to elevated plasma concentrations and bleeding risk.

What should I do if I'm prescribed both?

Reduce dabigatran dose to 110 mg twice daily when co-administered, especially in patients with CrCl 30–50 mL/min. Monitor for bleeding signs and consider alternative anticoagulation in elderly patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.