Amphotericin B and Tacrolimus: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Amphotericin B and Tacrolimus unless specifically directed by your doctor.
How Amphotericin B interacts with Tacrolimus
Both agents cause direct nephrotoxicity through afferent arteriolar vasoconstriction and tubular injury, producing additive renal damage and electrolyte disturbances such as hypomagnesemia and hypokalemia.
What you should do
Monitor renal function, magnesium and potassium daily; consider liposomal amphotericin formulation and reduce tacrolimus dose to target lower troughs.
Key facts
Severity
Major — avoid combination
Mechanism
Both agents cause direct nephrotoxicity through afferent arteriolar vasoconstriction and tubular injury, producing addit...
Action
Monitor renal function, magnesium and potassium daily; consider liposomal amphotericin formulation and reduce tacrolimus...
Frequently asked questions
Can I take Amphotericin B and Tacrolimus together?
No — this combination should generally be avoided. Monitor renal function, magnesium and potassium daily; consider liposomal amphotericin formulation and reduce tacrolimus dose to target lower troughs.
What is the severity of this interaction?
The interaction between Amphotericin B and Tacrolimus is classified as Major — avoid combination. Both agents cause direct nephrotoxicity through afferent arteriolar vasoconstriction and tubular injury, producing additive renal damage and electrolyte disturbances such as hypomagnesemia and hypokalemia.
What should I do if I'm prescribed both?
Monitor renal function, magnesium and potassium daily; consider liposomal amphotericin formulation and reduce tacrolimus dose to target lower troughs. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.