Nsaid and Tacrolimus: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Nsaid and Tacrolimus unless specifically directed by your doctor.
How Nsaid interacts with Tacrolimus
NSAIDs reduce renal prostaglandin synthesis and afferent arteriolar vasodilation, exacerbating tacrolimus-induced nephrotoxicity.
What you should do
Avoid chronic NSAID use in transplant patients on tacrolimus; if short-term use is unavoidable, monitor serum creatinine and tacrolimus trough levels closely.
Key facts
Severity
Major — avoid combination
Mechanism
NSAIDs reduce renal prostaglandin synthesis and afferent arteriolar vasodilation, exacerbating tacrolimus-induced nephro...
Action
Avoid chronic NSAID use in transplant patients on tacrolimus; if short-term use is unavoidable, monitor serum creatinine...
Frequently asked questions
Can I take Nsaid and Tacrolimus together?
No — this combination should generally be avoided. Avoid chronic NSAID use in transplant patients on tacrolimus; if short-term use is unavoidable, monitor serum creatinine and tacrolimus trough levels closely.
What is the severity of this interaction?
The interaction between Nsaid and Tacrolimus is classified as Major — avoid combination. NSAIDs reduce renal prostaglandin synthesis and afferent arteriolar vasodilation, exacerbating tacrolimus-induced nephrotoxicity.
What should I do if I'm prescribed both?
Avoid chronic NSAID use in transplant patients on tacrolimus; if short-term use is unavoidable, monitor serum creatinine and tacrolimus trough levels closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.