Atorvastatin and Digoxin: Drug Interaction Guide

Quick answer: Atorvastatin and Digoxin have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Atorvastatin interacts with Digoxin

Atorvastatin may modestly inhibit intestinal P-glycoprotein, increasing digoxin exposure in some patients.

What you should do

Usually no dose change is needed. Monitor digoxin levels and toxicity symptoms in older patients, renal impairment, or high-dose atorvastatin use.

Key facts

Severity

Minor — typically manageable

Mechanism

Atorvastatin may modestly inhibit intestinal P-glycoprotein, increasing digoxin exposure in some patients.

Action

Usually no dose change is needed. Monitor digoxin levels and toxicity symptoms in older patients, renal impairment, or h...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Atorvastatin and Digoxin together?

Usually yes, with awareness. Usually no dose change is needed. Monitor digoxin levels and toxicity symptoms in older patients, renal impairment, or high-dose atorvastatin use.

What is the severity of this interaction?

The interaction between Atorvastatin and Digoxin is classified as Minor — typically manageable. Atorvastatin may modestly inhibit intestinal P-glycoprotein, increasing digoxin exposure in some patients.

What should I do if I'm prescribed both?

Usually no dose change is needed. Monitor digoxin levels and toxicity symptoms in older patients, renal impairment, or high-dose atorvastatin use. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.