Digoxin and Omeprazole: Drug Interaction Guide

Quick answer: Digoxin and Omeprazole have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Digoxin interacts with Omeprazole

Omeprazole may modestly increase digoxin exposure through altered gastric pH and possible P-glycoprotein effects.

What you should do

Usually no pre-emptive dose change is required, but monitor for digoxin toxicity in older adults or patients with renal impairment.

Key facts

Severity

Minor — typically manageable

Mechanism

Omeprazole may modestly increase digoxin exposure through altered gastric pH and possible P-glycoprotein effects.

Action

Usually no pre-emptive dose change is required, but monitor for digoxin toxicity in older adults or patients with renal ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Digoxin and Omeprazole together?

Usually yes, with awareness. Usually no pre-emptive dose change is required, but monitor for digoxin toxicity in older adults or patients with renal impairment.

What is the severity of this interaction?

The interaction between Digoxin and Omeprazole is classified as Minor — typically manageable. Omeprazole may modestly increase digoxin exposure through altered gastric pH and possible P-glycoprotein effects.

What should I do if I'm prescribed both?

Usually no pre-emptive dose change is required, but monitor for digoxin toxicity in older adults or patients with renal impairment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.