Carbamazepine and Rivaroxaban: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Carbamazepine and Rivaroxaban unless specifically directed by your doctor.
How Carbamazepine interacts with Rivaroxaban
Carbamazepine induces both CYP3A4 and P-glycoprotein, reducing rivaroxaban exposure by approximately 50% and increasing risk of thromboembolism.
What you should do
Avoid combination. Use an alternative anticoagulant (e.g., LMWH or warfarin with INR monitoring) or alternative anticonvulsant.
Key facts
Severity
Major — avoid combination
Mechanism
Carbamazepine induces both CYP3A4 and P-glycoprotein, reducing rivaroxaban exposure by approximately 50% and increasing ...
Action
Avoid combination. Use an alternative anticoagulant (e.g., LMWH or warfarin with INR monitoring) or alternative anticonv...
Frequently asked questions
Can I take Carbamazepine and Rivaroxaban together?
No — this combination should generally be avoided. Avoid combination. Use an alternative anticoagulant (e.g., LMWH or warfarin with INR monitoring) or alternative anticonvulsant.
What is the severity of this interaction?
The interaction between Carbamazepine and Rivaroxaban is classified as Major — avoid combination. Carbamazepine induces both CYP3A4 and P-glycoprotein, reducing rivaroxaban exposure by approximately 50% and increasing risk of thromboembolism.
What should I do if I'm prescribed both?
Avoid combination. Use an alternative anticoagulant (e.g., LMWH or warfarin with INR monitoring) or alternative anticonvulsant. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.