Rifampicin and Rivaroxaban: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Rifampicin and Rivaroxaban unless specifically directed by your doctor.
How Rifampicin interacts with Rivaroxaban
Rifampicin is a strong inducer of CYP3A4 and P-glycoprotein, markedly reducing rivaroxaban exposure and risking thrombotic failure.
What you should do
Avoid combination. Use an alternative anticoagulant such as a vitamin K antagonist or low-molecular-weight heparin with appropriate monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin is a strong inducer of CYP3A4 and P-glycoprotein, markedly reducing rivaroxaban exposure and risking thrombot...
Action
Avoid combination. Use an alternative anticoagulant such as a vitamin K antagonist or low-molecular-weight heparin with ...
Frequently asked questions
Can I take Rifampicin and Rivaroxaban together?
No — this combination should generally be avoided. Avoid combination. Use an alternative anticoagulant such as a vitamin K antagonist or low-molecular-weight heparin with appropriate monitoring.
What is the severity of this interaction?
The interaction between Rifampicin and Rivaroxaban is classified as Major — avoid combination. Rifampicin is a strong inducer of CYP3A4 and P-glycoprotein, markedly reducing rivaroxaban exposure and risking thrombotic failure.
What should I do if I'm prescribed both?
Avoid combination. Use an alternative anticoagulant such as a vitamin K antagonist or low-molecular-weight heparin with appropriate monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.