Celecoxib and Lithium: Drug Interaction Guide

Quick answer: This combination requires caution. Celecoxib and Lithium can be used together with adjustments and monitoring.

How Celecoxib interacts with Lithium

Celecoxib can reduce renal prostaglandin synthesis, lowering renal lithium clearance. This may increase lithium concentrations and toxicity risk.

What you should do

Check lithium levels after starting or stopping celecoxib and monitor for tremor, confusion, diarrhea, or renal impairment.

Key facts

Severity

Moderate — caution required

Mechanism

Celecoxib can reduce renal prostaglandin synthesis, lowering renal lithium clearance. This may increase lithium concentr...

Action

Check lithium levels after starting or stopping celecoxib and monitor for tremor, confusion, diarrhea, or renal impairme...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Celecoxib and Lithium together?

With caution. Check lithium levels after starting or stopping celecoxib and monitor for tremor, confusion, diarrhea, or renal impairment.

What is the severity of this interaction?

The interaction between Celecoxib and Lithium is classified as Moderate — caution required. Celecoxib can reduce renal prostaglandin synthesis, lowering renal lithium clearance. This may increase lithium concentrations and toxicity risk.

What should I do if I'm prescribed both?

Check lithium levels after starting or stopping celecoxib and monitor for tremor, confusion, diarrhea, or renal impairment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 22, 2026 by iMedic Medical Editorial Team. Our editorial process.