Ciclosporin and Grapefruit Juice: Drug Interaction Guide

Quick answer: This combination requires caution. Ciclosporin and Grapefruit Juice can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ciclosporin interacts with Grapefruit Juice

Furanocoumarins in grapefruit juice irreversibly inhibit intestinal CYP3A4, increasing oral bioavailability of ciclosporin and yielding unpredictable trough concentrations.

What you should do

Advise transplant patients to avoid grapefruit and grapefruit juice. If ingested, repeat ciclosporin trough levels within a week to reassess dosing.

Key facts

Severity

Moderate — caution required

Mechanism

Furanocoumarins in grapefruit juice irreversibly inhibit intestinal CYP3A4, increasing oral bioavailability of ciclospor...

Action

Advise transplant patients to avoid grapefruit and grapefruit juice. If ingested, repeat ciclosporin trough levels withi...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ciclosporin and Grapefruit Juice together?

With caution. Advise transplant patients to avoid grapefruit and grapefruit juice. If ingested, repeat ciclosporin trough levels within a week to reassess dosing.

What is the severity of this interaction?

The interaction between Ciclosporin and Grapefruit Juice is classified as Moderate — caution required. Furanocoumarins in grapefruit juice irreversibly inhibit intestinal CYP3A4, increasing oral bioavailability of ciclosporin and yielding unpredictable trough concentrations.

What should I do if I'm prescribed both?

Advise transplant patients to avoid grapefruit and grapefruit juice. If ingested, repeat ciclosporin trough levels within a week to reassess dosing. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.