Grapefruit Juice and Nifedipine: Drug Interaction Guide

Quick answer: This combination requires caution. Grapefruit Juice and Nifedipine can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Grapefruit Juice interacts with Nifedipine

Grapefruit juice inhibits intestinal CYP3A4, increasing nifedipine bioavailability. This can enhance vasodilation and cause hypotension, flushing, or dizziness.

What you should do

Advise patients to avoid grapefruit products during nifedipine therapy. Monitor blood pressure if exposure occurs.

Key facts

Severity

Moderate — caution required

Mechanism

Grapefruit juice inhibits intestinal CYP3A4, increasing nifedipine bioavailability. This can enhance vasodilation and ca...

Action

Advise patients to avoid grapefruit products during nifedipine therapy. Monitor blood pressure if exposure occurs.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Grapefruit Juice and Nifedipine together?

With caution. Advise patients to avoid grapefruit products during nifedipine therapy. Monitor blood pressure if exposure occurs.

What is the severity of this interaction?

The interaction between Grapefruit Juice and Nifedipine is classified as Moderate — caution required. Grapefruit juice inhibits intestinal CYP3A4, increasing nifedipine bioavailability. This can enhance vasodilation and cause hypotension, flushing, or dizziness.

What should I do if I'm prescribed both?

Advise patients to avoid grapefruit products during nifedipine therapy. Monitor blood pressure if exposure occurs. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.