Ciclosporin and St Johns Wort: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ciclosporin and St Johns Wort unless specifically directed by your doctor.
How Ciclosporin interacts with St Johns Wort
St John's wort induces CYP3A4 and P-glycoprotein, substantially reducing ciclosporin concentrations and risking transplant rejection.
What you should do
Contraindicated in transplant recipients. Counsel patients to avoid herbal products and review medication lists at every transplant visit.
Key facts
Severity
Major — avoid combination
Mechanism
St John's wort induces CYP3A4 and P-glycoprotein, substantially reducing ciclosporin concentrations and risking transpla...
Action
Contraindicated in transplant recipients. Counsel patients to avoid herbal products and review medication lists at every...
Frequently asked questions
Can I take Ciclosporin and St Johns Wort together?
No — this combination should generally be avoided. Contraindicated in transplant recipients. Counsel patients to avoid herbal products and review medication lists at every transplant visit.
What is the severity of this interaction?
The interaction between Ciclosporin and St Johns Wort is classified as Major — avoid combination. St John's wort induces CYP3A4 and P-glycoprotein, substantially reducing ciclosporin concentrations and risking transplant rejection.
What should I do if I'm prescribed both?
Contraindicated in transplant recipients. Counsel patients to avoid herbal products and review medication lists at every transplant visit. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.