Ciclosporin and Verapamil: Drug Interaction Guide

Quick answer: This combination requires caution. Ciclosporin and Verapamil can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ciclosporin interacts with Verapamil

Verapamil inhibits CYP3A4 and P-glycoprotein, increasing ciclosporin concentrations. This raises the risk of nephrotoxicity, hypertension, and neurotoxicity.

What you should do

Monitor ciclosporin trough concentrations, renal function, and blood pressure; reduce ciclosporin dose if concentrations rise.

Key facts

Severity

Moderate — caution required

Mechanism

Verapamil inhibits CYP3A4 and P-glycoprotein, increasing ciclosporin concentrations. This raises the risk of nephrotoxic...

Action

Monitor ciclosporin trough concentrations, renal function, and blood pressure; reduce ciclosporin dose if concentrations...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ciclosporin and Verapamil together?

With caution. Monitor ciclosporin trough concentrations, renal function, and blood pressure; reduce ciclosporin dose if concentrations rise.

What is the severity of this interaction?

The interaction between Ciclosporin and Verapamil is classified as Moderate — caution required. Verapamil inhibits CYP3A4 and P-glycoprotein, increasing ciclosporin concentrations. This raises the risk of nephrotoxicity, hypertension, and neurotoxicity.

What should I do if I'm prescribed both?

Monitor ciclosporin trough concentrations, renal function, and blood pressure; reduce ciclosporin dose if concentrations rise. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.