Ciprofloxacin and Clozapine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ciprofloxacin and Clozapine unless specifically directed by your doctor.
How Ciprofloxacin interacts with Clozapine
Ciprofloxacin inhibits CYP1A2, the primary enzyme metabolising clozapine, leading to elevated clozapine levels and risk of seizures, sedation, and agranulocytosis-related toxicity.
What you should do
Avoid combination where possible; if required, reduce clozapine dose by approximately one-third and monitor clinical status and clozapine levels.
Key facts
Severity
Major — avoid combination
Mechanism
Ciprofloxacin inhibits CYP1A2, the primary enzyme metabolising clozapine, leading to elevated clozapine levels and risk ...
Action
Avoid combination where possible; if required, reduce clozapine dose by approximately one-third and monitor clinical sta...
Frequently asked questions
Can I take Ciprofloxacin and Clozapine together?
No — this combination should generally be avoided. Avoid combination where possible; if required, reduce clozapine dose by approximately one-third and monitor clinical status and clozapine levels.
What is the severity of this interaction?
The interaction between Ciprofloxacin and Clozapine is classified as Major — avoid combination. Ciprofloxacin inhibits CYP1A2, the primary enzyme metabolising clozapine, leading to elevated clozapine levels and risk of seizures, sedation, and agranulocytosis-related toxicity.
What should I do if I'm prescribed both?
Avoid combination where possible; if required, reduce clozapine dose by approximately one-third and monitor clinical status and clozapine levels. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.