Ciprofloxacin and Duloxetine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ciprofloxacin and Duloxetine unless specifically directed by your doctor.
How Ciprofloxacin interacts with Duloxetine
Ciprofloxacin strongly inhibits CYP1A2 which is the major metabolic pathway for duloxetine, raising duloxetine AUC up to 6-fold with risk of serotonergic and noradrenergic toxicity.
What you should do
Avoid combination. If a fluoroquinolone is required, choose levofloxacin or moxifloxacin which do not significantly inhibit CYP1A2.
Key facts
Severity
Major — avoid combination
Mechanism
Ciprofloxacin strongly inhibits CYP1A2 which is the major metabolic pathway for duloxetine, raising duloxetine AUC up to...
Action
Avoid combination. If a fluoroquinolone is required, choose levofloxacin or moxifloxacin which do not significantly inhi...
Frequently asked questions
Can I take Ciprofloxacin and Duloxetine together?
No — this combination should generally be avoided. Avoid combination. If a fluoroquinolone is required, choose levofloxacin or moxifloxacin which do not significantly inhibit CYP1A2.
What is the severity of this interaction?
The interaction between Ciprofloxacin and Duloxetine is classified as Major — avoid combination. Ciprofloxacin strongly inhibits CYP1A2 which is the major metabolic pathway for duloxetine, raising duloxetine AUC up to 6-fold with risk of serotonergic and noradrenergic toxicity.
What should I do if I'm prescribed both?
Avoid combination. If a fluoroquinolone is required, choose levofloxacin or moxifloxacin which do not significantly inhibit CYP1A2. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.