Ciprofloxacin and Rasagiline: Drug Interaction Guide
Quick answer: This combination requires caution. Ciprofloxacin and Rasagiline can be used together with adjustments and monitoring.
How Ciprofloxacin interacts with Rasagiline
Ciprofloxacin is a potent CYP1A2 inhibitor that reduces the metabolism of rasagiline, increasing plasma concentrations and potentially compromising MAO-B selectivity.
What you should do
Limit rasagiline to 0.5 mg daily during ciprofloxacin therapy and monitor blood pressure. Consider levofloxacin or other non-CYP1A2 inhibitor antibiotic as alternative.
Key facts
Severity
Moderate — caution required
Mechanism
Ciprofloxacin is a potent CYP1A2 inhibitor that reduces the metabolism of rasagiline, increasing plasma concentrations a...
Action
Limit rasagiline to 0.5 mg daily during ciprofloxacin therapy and monitor blood pressure. Consider levofloxacin or other...
Frequently asked questions
Can I take Ciprofloxacin and Rasagiline together?
With caution. Limit rasagiline to 0.5 mg daily during ciprofloxacin therapy and monitor blood pressure. Consider levofloxacin or other non-CYP1A2 inhibitor antibiotic as alternative.
What is the severity of this interaction?
The interaction between Ciprofloxacin and Rasagiline is classified as Moderate — caution required. Ciprofloxacin is a potent CYP1A2 inhibitor that reduces the metabolism of rasagiline, increasing plasma concentrations and potentially compromising MAO-B selectivity.
What should I do if I'm prescribed both?
Limit rasagiline to 0.5 mg daily during ciprofloxacin therapy and monitor blood pressure. Consider levofloxacin or other non-CYP1A2 inhibitor antibiotic as alternative. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.