Cisplatin and Vancomycin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Cisplatin and Vancomycin unless specifically directed by your doctor.
How Cisplatin interacts with Vancomycin
Both agents cause direct nephrotoxicity through proximal tubular damage and oxidative stress, with additive injury when combined; cisplatin also enhances vancomycin accumulation via reduced clearance.
What you should do
Avoid combination when possible; if necessary, monitor renal function and vancomycin trough levels daily, and ensure adequate hydration.
Key facts
Severity
Major — avoid combination
Mechanism
Both agents cause direct nephrotoxicity through proximal tubular damage and oxidative stress, with additive injury when ...
Action
Avoid combination when possible; if necessary, monitor renal function and vancomycin trough levels daily, and ensure ade...
Frequently asked questions
Can I take Cisplatin and Vancomycin together?
No — this combination should generally be avoided. Avoid combination when possible; if necessary, monitor renal function and vancomycin trough levels daily, and ensure adequate hydration.
What is the severity of this interaction?
The interaction between Cisplatin and Vancomycin is classified as Major — avoid combination. Both agents cause direct nephrotoxicity through proximal tubular damage and oxidative stress, with additive injury when combined; cisplatin also enhances vancomycin accumulation via reduced clearance.
What should I do if I'm prescribed both?
Avoid combination when possible; if necessary, monitor renal function and vancomycin trough levels daily, and ensure adequate hydration. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.