Cisplatin and Gentamicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Cisplatin and Gentamicin unless specifically directed by your doctor.
How Cisplatin interacts with Gentamicin
Cisplatin and gentamicin both cause renal tubular toxicity, producing additive nephrotoxicity. Impaired renal function can further increase aminoglycoside exposure.
What you should do
Avoid concurrent use if alternatives exist. If unavoidable, monitor renal function and gentamicin levels closely and ensure hydration.
Key facts
Severity
Major — avoid combination
Mechanism
Cisplatin and gentamicin both cause renal tubular toxicity, producing additive nephrotoxicity. Impaired renal function c...
Action
Avoid concurrent use if alternatives exist. If unavoidable, monitor renal function and gentamicin levels closely and ens...
Frequently asked questions
Can I take Cisplatin and Gentamicin together?
No — this combination should generally be avoided. Avoid concurrent use if alternatives exist. If unavoidable, monitor renal function and gentamicin levels closely and ensure hydration.
What is the severity of this interaction?
The interaction between Cisplatin and Gentamicin is classified as Major — avoid combination. Cisplatin and gentamicin both cause renal tubular toxicity, producing additive nephrotoxicity. Impaired renal function can further increase aminoglycoside exposure.
What should I do if I'm prescribed both?
Avoid concurrent use if alternatives exist. If unavoidable, monitor renal function and gentamicin levels closely and ensure hydration. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.