Clarithromycin and Quetiapine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Clarithromycin and Quetiapine unless specifically directed by your doctor.
How Clarithromycin interacts with Quetiapine
Clarithromycin strongly inhibits CYP3A4, the primary enzyme responsible for quetiapine metabolism. Quetiapine exposure can increase, causing excessive sedation, hypotension, and QT prolongation.
What you should do
Avoid the combination when possible. Use an alternative antibiotic or temporarily reduce or hold quetiapine with close monitoring if coadministration is unavoidable.
Key facts
Severity
Major — avoid combination
Mechanism
Clarithromycin strongly inhibits CYP3A4, the primary enzyme responsible for quetiapine metabolism. Quetiapine exposure c...
Action
Avoid the combination when possible. Use an alternative antibiotic or temporarily reduce or hold quetiapine with close m...
Frequently asked questions
Can I take Clarithromycin and Quetiapine together?
No — this combination should generally be avoided. Avoid the combination when possible. Use an alternative antibiotic or temporarily reduce or hold quetiapine with close monitoring if coadministration is unavoidable.
What is the severity of this interaction?
The interaction between Clarithromycin and Quetiapine is classified as Major — avoid combination. Clarithromycin strongly inhibits CYP3A4, the primary enzyme responsible for quetiapine metabolism. Quetiapine exposure can increase, causing excessive sedation, hypotension, and QT prolongation.
What should I do if I'm prescribed both?
Avoid the combination when possible. Use an alternative antibiotic or temporarily reduce or hold quetiapine with close monitoring if coadministration is unavoidable. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.