Clarithromycin and Ticagrelor: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Clarithromycin and Ticagrelor unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Clarithromycin interacts with Ticagrelor

Clarithromycin is a potent CYP3A4 inhibitor that markedly increases ticagrelor exposure, raising the risk of major bleeding and bradyarrhythmia.

What you should do

Avoid combination. Substitute azithromycin or another non-CYP3A4-inhibiting antibiotic.

Key facts

Severity

Major — avoid combination

Mechanism

Clarithromycin is a potent CYP3A4 inhibitor that markedly increases ticagrelor exposure, raising the risk of major bleed...

Action

Avoid combination. Substitute azithromycin or another non-CYP3A4-inhibiting antibiotic.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Ticagrelor together?

No — this combination should generally be avoided. Avoid combination. Substitute azithromycin or another non-CYP3A4-inhibiting antibiotic.

What is the severity of this interaction?

The interaction between Clarithromycin and Ticagrelor is classified as Major — avoid combination. Clarithromycin is a potent CYP3A4 inhibitor that markedly increases ticagrelor exposure, raising the risk of major bleeding and bradyarrhythmia.

What should I do if I'm prescribed both?

Avoid combination. Substitute azithromycin or another non-CYP3A4-inhibiting antibiotic. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.