Clarithromycin and Verapamil: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Clarithromycin and Verapamil unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Clarithromycin interacts with Verapamil

Clarithromycin inhibits CYP3A4-mediated verapamil metabolism, elevating concentrations and increasing risk of bradycardia, AV block, and hypotension, particularly in older patients.

What you should do

Avoid the combination, especially in elderly or renally impaired patients; use azithromycin or doxycycline as alternative antibiotics.

Key facts

Severity

Major — avoid combination

Mechanism

Clarithromycin inhibits CYP3A4-mediated verapamil metabolism, elevating concentrations and increasing risk of bradycardi...

Action

Avoid the combination, especially in elderly or renally impaired patients; use azithromycin or doxycycline as alternativ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Verapamil together?

No — this combination should generally be avoided. Avoid the combination, especially in elderly or renally impaired patients; use azithromycin or doxycycline as alternative antibiotics.

What is the severity of this interaction?

The interaction between Clarithromycin and Verapamil is classified as Major — avoid combination. Clarithromycin inhibits CYP3A4-mediated verapamil metabolism, elevating concentrations and increasing risk of bradycardia, AV block, and hypotension, particularly in older patients.

What should I do if I'm prescribed both?

Avoid the combination, especially in elderly or renally impaired patients; use azithromycin or doxycycline as alternative antibiotics. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.