Colestyramine and Digoxin: Drug Interaction Guide
Quick answer: Colestyramine and Digoxin have a minor interaction — typically manageable with awareness.
How Colestyramine interacts with Digoxin
Colestyramine binds digoxin in the gut, reducing oral absorption and enterohepatic recycling and modestly lowering digoxin plasma levels.
What you should do
Administer digoxin at least 1 hour before or 4-6 hours after colestyramine and monitor for adequate clinical effect, with digoxin level if clinically indicated.
Key facts
Severity
Minor — typically manageable
Mechanism
Colestyramine binds digoxin in the gut, reducing oral absorption and enterohepatic recycling and modestly lowering digox...
Action
Administer digoxin at least 1 hour before or 4-6 hours after colestyramine and monitor for adequate clinical effect, wit...
Frequently asked questions
Can I take Colestyramine and Digoxin together?
Usually yes, with awareness. Administer digoxin at least 1 hour before or 4-6 hours after colestyramine and monitor for adequate clinical effect, with digoxin level if clinically indicated.
What is the severity of this interaction?
The interaction between Colestyramine and Digoxin is classified as Minor — typically manageable. Colestyramine binds digoxin in the gut, reducing oral absorption and enterohepatic recycling and modestly lowering digoxin plasma levels.
What should I do if I'm prescribed both?
Administer digoxin at least 1 hour before or 4-6 hours after colestyramine and monitor for adequate clinical effect, with digoxin level if clinically indicated. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.