Colestyramine and Pravastatin: Drug Interaction Guide

Quick answer: Colestyramine and Pravastatin have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Colestyramine interacts with Pravastatin

Colestyramine can bind pravastatin within the intestine and reduce its absorption when the medicines are taken together.

What you should do

Give pravastatin at least one hour before or four hours after colestyramine. Monitor lipid response if adherence to dose separation is difficult.

Key facts

Severity

Minor — typically manageable

Mechanism

Colestyramine can bind pravastatin within the intestine and reduce its absorption when the medicines are taken together.

Action

Give pravastatin at least one hour before or four hours after colestyramine. Monitor lipid response if adherence to dose...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Colestyramine and Pravastatin together?

Usually yes, with awareness. Give pravastatin at least one hour before or four hours after colestyramine. Monitor lipid response if adherence to dose separation is difficult.

What is the severity of this interaction?

The interaction between Colestyramine and Pravastatin is classified as Minor — typically manageable. Colestyramine can bind pravastatin within the intestine and reduce its absorption when the medicines are taken together.

What should I do if I'm prescribed both?

Give pravastatin at least one hour before or four hours after colestyramine. Monitor lipid response if adherence to dose separation is difficult. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.